Getting rid of 100 percent of mice requires a systematic integrated pest management approach that combines sanitation, exclusion, trapping, and monitoring, because a single method rarely eliminates them all. First, inspect your entire home including attic, basement, garage, kitchen, and exterior foundation for entry holes, droppings, gnaw marks, and nesting material. Mice can enter through a hole the size of a dime. Seal all holes with steel wool plus caulk or metal mesh, especially around pipes, vents, doors, and utility lines. Second, remove attractants by storing all food including pet food and bird seed in airtight metal or glass containers, cleaning crumbs daily, taking out trash, fixing leaks, and decluttering cardboard boxes and fabric piles that serve as nests. Third, use multiple traps at once, six to ten snap traps or electronic traps baited with peanut butter placed perpendicular to walls where droppings are found, checking daily. Avoid relying solely on poison because mice may die in walls and cause odor. Fourth, follow the five to seven day rule of no new signs before declaring success, and keep monitoring. For heavy infestations, call a licensed pest control professional who can use commercial grade exclusion and trapping. Complete elimination is possible but requires persistence for several weeks.
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