Will PrEP work after 3 days? After 3 days of daily oral PrEP, drug levels are building up but have not yet reached the levels shown to provide maximum protection in clinical trials. PrEP is not an emergency medication like PEP. If you had a potential HIV exposure in the last 72 hours, PrEP is not the right tool, you should ask about PEP (post-exposure prophylaxis), which is a 28-day course that must be started as soon as possible. For future protection, if you start daily Truvada or Descovy today, you should continue taking it daily and use condoms or other prevention methods during the lead-in period. For anal sex, CDC guidance points to 7 days of daily dosing to reach high protection. For receptive vaginal sex, it takes up to 21 days. Taking it for 3 days and then stopping does not give lasting protection. If you struggle with daily pills, ask a healthcare provider about injectable cabotegravir every 2 months. A sexual health clinic can help you choose and time it correctly.
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