The failure rate of PrEP is exceptionally low when the medication is taken correctly and consistently as prescribed by a healthcare provider. Clinical data demonstrates that daily oral PrEP reduces the risk of contracting HIV from sexual contact by roughly ninety-nine percent. Instances where PrEP technically "fails" and an infection occurs are almost exclusively linked to poor adherence, where individuals skipped multiple doses and failed to maintain adequate drug levels in their tissues. When used faithfully according to guidelines, breakthrough infections are statistically exceedingly rare.
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