When taking oral PrEP medications, patients should avoid certain substances and drug interactions that could potentially compromise kidney health or reduce treatment efficacy. Most notably, individuals should avoid taking high doses of nonsteroidal anti-inflammatory drugs regularly without medical supervision, as these can strain kidney function when combined with certain PrEP formulations. Additionally, patients should avoid sharing their medication, missing scheduled lab work, or purchasing unregulated supplements that lack FDA approval. Consulting a healthcare provider before starting new over-the-counter medications ensures long-term safety and protection.
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