The primary antagonist changes across different eras of the overarching saga. In the early imperial eras, the rigid, stagnant, and tyrannical Galactic Empire—embodied by the immortal genetic dynasty of Cleons—serves as the systemic antagonist. Later, the primary external existential threat becomes the Mule, a mutant conqueror wielding devastating mentalic powers of emotional subjugation, while institutional dogmatism and human nature continually threaten Seldon's Plan.
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