What can I spray on my bed to prevent bed bugs?

To prevent bed bugs, you can spray certain products on your bed, but sprays alone will not guarantee prevention and should be part of integrated approach with encasements, vacuuming, and inspection. Preventive sprays that are low toxicity and can be used on beds include bed bug proof mattress and pillow encasements which are not sprays but physical barriers that are most effective, and for sprays, essential oil based sprays like cedar oil, peppermint oil, and neem oil sprays that are labeled for bed bugs and have some repellent effect, though they have limited residual killing power. Desiccant dusts like CimeXa or food grade diatomaceous earth can be lightly dusted in cracks and crevices around bed frame, not directly on mattress surface where you sleep, as they kill by dehydrating bugs but take days. Residual insecticides labeled for bed bugs such as pyrethroid sprays can be applied to bed frame cracks and baseboards by professionals, but many bed bugs are resistant and you should not spray mattress directly with harsh insecticides where you sleep. The most effective prevention is not a spray but encasing mattress and box spring in bed bug proof encasements, using interceptor traps under bed legs, washing bedding weekly on high heat, vacuuming mattress seams regularly, and inspecting second hand furniture before bringing home. For travel, spray luggage with repellent and wash clothes on high heat after trips.