Accidentally sleeping in scleral lenses can restrict oxygen flow to the cornea and trap debris or microorganisms underneath the large fluid-filled lens reservoir, increasing the risk of infection or corneal irritation. If you wake up with them in, do not immediately try to force or yank them out dry, as the suction can damage the corneal tissue. Instead, lubricate your eyes generously with preservative-free rewetting drops or saline solution, blink gently until the lenses loosen up and move freely, and then safely remove them. Monitor your eyes closely for redness, pain, or blurred vision, and consult an optometrist if symptoms persist.