Oprah Winfrey does not have a son; she has never biological children. When she was a teenager, she gave birth prematurely to a baby boy who tragically passed away shortly after birth due to severe complications. Over the years, she has spoken openly about this deeply personal loss and how it shaped her perspective on motherhood, leading her instead to focus her nurturing instincts on mentorship, educational philanthropy, and founding the Oprah Winfrey Leadership Academy for Girls in South Africa.