Krystal Biotech's primary corporate and administrative headquarters are situated in Pittsburgh, Pennsylvania, within the United States. This central facility serves as the command center for executive leadership, corporate governance, strategic financial planning, and overarching business development initiatives. In close proximity to its administrative roots, the company also houses and maintains advanced research laboratories and specialized commercial manufacturing facilities designed to produce its clinical and commercial-grade gene therapy products under strict regulatory guidelines. While the Pittsburgh headquarters anchors the company's corporate identity, its operational footprint extends internationally through specialized subsidiaries and clinical study sites designed to support global patient access, regulatory filings, and international market distribution.