Krystal Biotech maintains its primary corporate headquarters and operational administrative center in Pittsburgh, Pennsylvania, within the United States. This strategic location houses executive management, corporate administration, and financial operations. In addition to its corporate headquarters, the company operates state-of-the-art, custom-built manufacturing and laboratory facilities—such as its dedicated commercial manufacturing plant—designed to support the end-to-end production of its complex gene therapy vectors under rigorous Current Good Manufacturing Practice (cGMP) standards. While its physical assets and primary research and development laboratories are anchored in Pennsylvania, the company operates globally, establishing international footprints and corporate engagements across Europe, Asia, and other key international territories to facilitate clinical development, regulatory submissions, and commercial distribution workflows.