Niagen (nicotinamide riboside, an NAD+ booster) is typically recommended to be taken in the morning with or without food. Because NAD levels fluctuate naturally in sync with the body's internal circadian rhythm and peak during daytime hours to support cellular energy production and metabolic processes, morning ingestion aligns best with natural physiological cycles. Taking it early in the day also helps prevent any potential minor sleep disturbances or nighttime stimulation that some sensitive individuals report with metabolic supplements.