Determining the single greatest upset in college basketball history usually points to legendary moments in the NCAA Division I Men's Basketball Tournament where a massive underdog shocks a heavily favored powerhouse. Widely celebrated candidates include Chaminade University's stunning victory over top-ranked Virginia in 1982, UMBC defeating top-seeded Virginia as a 16-seed in 2018, and various iconic conference tournament or March Madness buzzer-beaters that completely upended national championship brackets and captured the sporting world's imagination.