The largest brewing manufacturing operations in the United States are anchored by major industry giants such as Anheuser-Busch and Molson Coors, alongside expansive facilities managed by Constellation Brands and independent craft collectives. Anheuser-Busch's historic primary flagship brewery located in St. Louis, Missouri, remains one of the largest individual brewing complexes in the country, complemented by massive multi-state production plants designed to handle immense national distribution volumes.