In the science fiction thriller Splice, Dren undergoes a biological metamorphosis and turns male due to the unstable and unpredictable nature of the experimental animal and human DNA used to create her. Because her genetic makeup incorporates various species with unique biological adaptation traits—including amphibians capable of sex change—her body triggers a rapid transformation as she matures, developing male reproductive organs and physical strength, which ultimately drives the narrative toward its dark and unsettling climax.
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