The debate comparing the pure speed of Deion Sanders and Bo Jackson highlights two mythical athletic freaks of nature. Deion Sanders clocked a legendary 4.21-second 40-yard dash at the NFL Scouting Combine and used his blazing speed to lock down entire sides of the field as a shutdown cornerback, while Bo Jackson combined breathtaking top-end linear speed with staggering size and raw power on long runs. While Deion excelled in agility and quick-twitch acceleration, Bo possessed unmatched momentum in the open field, leaving their relative speed a legendary topic of debate.