The infamous distinction of throwing five interceptions in a single half of an NFL regular-season game belongs to Nathan Peterman, who endured a historically disastrous start during his rookie campaign with the Buffalo Bills. Playing against the Los Angeles Chargers defense, Peterman was thrust into his first career start and suffered an absolute nightmare performance during the first two quarters, repeatedly turning the ball over through a combination of poor decisions, heavy defensive pass rush pressure, and unfortunate tipped balls. By halftime, he had completed only a handful of passes while handing the opposing defense five separate interceptions, prompting the coaching staff to bench him immediately for the start of the third quarter to salvage the remainder of the contest. This shocking performance remains etched in modern football lore as one of the most difficult halves any professional signal-caller has ever endured, highlighting the immense physical and mental challenges rookies face when thrown into high-pressure starting roles against elite defensive units.