The undisputed and most intense historic rival for the Chicago Cubs is their fellow National League Central division opponent, the St. Louis Cardinals. The fierce rivalry between the Cubs and the Cardinals spans over a century of competitive baseball, featuring thousands of hard-fought divisional games, postseason battles, and intense competition for fan supremacy throughout the Midwest. Whenever these two storied franchises collide, whether at Wrigley Field or Busch Stadium, the games carry massive national attention, heightened emotions, and deep historical significance. While the Chicago White Sox represent a fun geographic crosstown opponent, the Cardinals remain the primary, historic nemesis in the minds of Cubs players and fans alike.