Thyroid Peroxidase (TPO) antibody levels above the standard laboratory reference cutoff—typically greater than 34 to 35 IU/mL, though specific thresholds vary by testing platform—are generally considered positive and strongly indicative of Hashimoto's thyroiditis. While mild elevations between 35 and 100 IU/mL can reflect early or borderline autoimmune activity, levels exceeding 100 IU/mL or very high readings surpassing 500 IU/mL point to robust autoimmune activity against the thyroid gland. A formal clinical diagnosis requires evaluating these antibody titers alongside thyroid hormone panels, TSH levels, and physical symptoms assessed by a physician.
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