The most successful prostate cancer treatment is highly individualized, depending entirely on the cancer's clinical stage, pathological grade, and the patient's overall health status. For early-stage, low-risk localized tumors, active surveillance offers exceptional success by avoiding treatment morbidity while closely monitoring the disease. For intermediate- and high-risk localized cancers, radical prostatectomy (surgical removal) and definitive radiation therapy combined with short- or long-term androgen deprivation therapy deliver proven, long-term cancer control and high cure rates, establishing them as clinical benchmark treatments.