Yes, prostate cancer can indeed recur following High-Intensity Focused Ultrasound (HIFU) therapy, just as it can after other localized treatments like radiation or surgery. While HIFU effectively targets and destroys localized cancerous tissue using focused sound waves while preserving surrounding healthy structures, microscopic cancer cells can occasionally remain dormant outside the focal zone or reappear elsewhere within the prostate gland over time. Urological oncologists monitor patients closely using regular prostate-specific antigen blood tests, MRI scans, and follow-up biopsies to detect any signs of biochemical or clinical recurrence early.