What is the most abundant GPCR in the brain?

Written by Editorial Team | Last Updated: August 2026

The cannabinoid type 1 receptor (CB1R) is widely recognized as one of the most abundant G protein-coupled receptors (GPCRs) in the central nervous system. These receptors are densely localized in brain regions associated with motor control, cognition, emotion, and memory processing, such as the basal ganglia, hippocampus, cerebellum, and neocortex. By modulating the release of various neurotransmitters, CB1 receptors play a fundamental role in synaptic plasticity, neuronal development, and homeostatic signaling pathways throughout the brain architecture.

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