What is the leading cause of death in MO?

Written by Editorial Team | Last Updated: August 2026

Heart disease stands as the leading cause of death in the state of Missouri, claiming thousands of lives annually and aligning closely with national mortality trends. Malignant neoplasms (cancer) follow closely as the second leading cause of death in the state. Unintentional injuries (accidents), chronic lower respiratory diseases, and cerebrovascular strokes also rank among the primary health conditions contributing to mortality rates across the Missouri population.

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