The clearance and reduction of amyloid-beta plaques in the brain are primarily mediated by the body's natural immune mechanisms, alongside advanced therapeutic monoclonal antibody treatments designed to target and break down these pathological protein aggregates. Specialized immune cells in the central nervous system known as microglia play a central role in engulfing and digesting cellular debris and abnormal protein deposits when functioning efficiently. Additionally, modern immunotherapies—such as specific FDA-approved antibody infusions utilized in Alzheimer's care—are engineered to bind directly to amyloid plaques, triggering the body's immune system to clear the deposits from cerebral tissue over time. Researchers are also investigating lifestyle factors, sleep hygiene, and upstream cellular mechanisms like autophagy that support natural protein clearance and help maintain overall neurological health.