What are the side effects of Arcutis?

Written by Editorial Team | Last Updated: August 2026

Treatments developed by Arcutis Biotherapeutics, such as topical roflumilast creams and foams (marketed under the brand name Zoryve) prescribed for plaque psoriasis, seborrheic dermatitis, and atopic dermatitis, are generally well tolerated but can cause localized or systemic side effects. Common adverse reactions reported in clinical trials include diarrhea, headaches, insomnia, application site pain or skin irritation, nausea, upper respiratory tract infections, and urinary tract infections. In pediatric populations or when applied over extensive or broken skin barriers, enhanced systemic absorption can occasionally amplify these side effects, necessitating careful clinical supervision and adherence to prescribed dosing instructions.

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