Sleeping with an ambulatory infusion pump requires careful organization of the equipment and tubing to ensure comfort while preventing accidental line dislodgement, kinking, or alarms. Patients typically place the compact pump inside a specialized carrying pouch, holster, or small basket secured safely close to the bed rather than directly under the body. Securing the intravenous tubing with medical tape against the skin or pajamas prevents snagging, and arranging the power cords or alarm units within easy earshot ensures any occlusion or low-battery warnings are addressed promptly.