Certain individuals should strictly avoid taking 5-HTP supplements to prevent serious adverse medical complications. This includes pregnant or breastfeeding women due to a lack of safety data, individuals taking prescription antidepressant medications (such as SSRIs, SNRIs, or MAOIs) due to the risk of serotonin syndrome, people suffering from severe liver disease, and individuals preparing for scheduled surgeries where neurotransmitter stability is critical.
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