In the storied history of the NCAA Division I Men's Basketball Tournament, numerous stunning upsets have captured national attention, but the ultimate pinnacle of underdog achievement belongs to lower-seeded Cinderella runs. While historic opening-round upsets feature massive point-spread underdogs like 15-seeds defeating 2-seeds, tournament runs by teams like Villanova in 1985 as an eighth seed or historic deep tournament breakthroughs by double-digit seeds remain legendary for defying all statistical odds.