Debating the greatest running back in the storied history of the University of Southern California involves choosing between legendary Heisman Trophy winners and Pro Football Hall of Famers who dominated the gridiron. Marcus Allen achieved historic greatness by becoming the first college player to rush for over two thousand yards in a single season, capturing the Heisman in 1981. Meanwhile, O.J. Simpson rushed for staggering numbers and captured the 1968 Heisman, while Reggie Bush electrified fans with breathtaking playmaking versatility.