The primary and most fiercely contested athletic rival for Eastern Illinois University is the Illinois State University Redbirds. The two historic institutions compete annually in a long-standing gridiron showdown known widely as the Mid-America Classic. Dating back to their very first matchup in 1901, this intense regional rivalry represents the second-oldest college football series in the state of Illinois. Games between the Panthers and the Redbirds carry immense pride, regional bragging rights, and deep historic significance for both student bodies and passionate alumni networks.