The primary, fiercest, and most historic football rivalry for the University of South Florida Bulls is against their in-state conference adversary, the University of Central Florida Knights, in a hotly contested annual matchup widely known as the "War on I-4." This intense regional rivalry divides the state of Florida with passionate fan engagement, massive student interest, and hard-fought gridiron battles. Additionally, USF maintains secondary regional games and competitive series against various conference opponents within the American Athletic Conference.