In the global pharmaceutical supply chain, the distribution network is overwhelmingly dominated by the major three multinational healthcare logistics giants commonly referred to as the Big Three. These industry-leading master distributors comprise AmerisourceBergen (now operating as Cencora), McKesson Corporation, and Cardinal Health. These massive enterprises manage complex, highly automated logistics pipelines that securely transport prescription drugs, biological therapeutics, and medical devices from manufacturing plants to retail pharmacies, hospitals, and healthcare clinics on a massive global scale, ensuring uninterrupted medical product availability.