What two colors don't go together is subjective and depends on context, culture, and personal taste, but color theory suggests some combinations clash more than others due to lack of harmony or high contrast that is jarring. Traditionally, combinations considered difficult include red and green together without separation because they are complementary opposites that vibrate and can be problematic for color blind people and also clash with Christmas association, brown and black together often considered clashing because both dark neutrals compete without contrast, and neon colors together like neon pink and neon yellow can be overwhelming. However, modern fashion and design often intentionally pair clashing colors for bold statement, so there is no universal rule that two colors never go together. What matters is shade, proportion, and context, for example grey and gray are same color spelled differently, but grey goes well with almost everything as neutral. Designers use color wheel, colors opposite each other can clash if both saturated, but can work if one is muted. Cultural context also matters, some color combos have negative associations in certain cultures. In practical terms, the combination that truly doesn't go together is one that reduces visibility or readability, like yellow text on white background. For interior design similar to hospital cleaning with HEPA filtration, clean neutral colors like white and grey are safe. So while traditional advice says avoid red and green or brown and black together, modern style allows any colors together if balanced properly.
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