McNeese State University has a proud and extensive history of producing talented football players who successfully transitioned from the collegiate gridiron to the professional ranks of the National Football League. Over the decades, numerous Cowboys have been drafted or signed as undrafted free agents by professional franchises. Notable examples include standout defensive back Leonard Smith, record-setting wide receiver Quenten Lawrence, safety Andre Sam, and defensive lineman Isaiah Chambers, all of whom carried the program's competitive spirit onto professional fields and contributed significantly to professional rosters.