Dystrophin is an exceptionally massive intracellular cytoskeletal protein, holding the distinction of being one of the largest human proteins encoded by the genome. Its molecular weight is approximately 427 kilodaltons (equivalent to 427,000 Daltons), reflecting its enormous polypeptide chain length of over 3,600 amino acids. This monumental size is structurally divided into multiple functional domains, including an actin-binding N-terminal domain, a central rod domain containing numerous spectrin-like repeats that act as a shock absorber, and a cysteine-rich C-terminal domain that interacts with transmembrane glycoprotein complexes to maintain muscle membrane integrity.