The AIM2 (Absent in Melanoma 2) protein has a calculated molecular weight of approximately 39 kilodaltons (kDa), consisting of roughly 343 amino acids. As a crucial component of the innate immune system, AIM2 acts as a cytoplasmic sensor that recognizes double-stranded DNA from pathogens or damaged cells, subsequently assembling into an inflammasome complex that triggers caspase-1 activation and pro-inflammatory cytokine release.