The Charlotte 49ers football schedule for the fall 2027 season features an exciting lineup of non-conference matchups and American Athletic Conference games. The early portion of the 2027 slate features a high-profile non-conference road game against the Ole Miss Rebels on September 4, followed by a home matchup against Elon on September 11, a battle against Appalachian State on September 18, and a road contest against the Old Dominion Monarchs on September 25, alongside subsequent conference games.