The global corporate headquarters of Spruce Biosciences, Inc. is located at 611 Gateway Boulevard, Suite 740, South San Francisco, California 94080, United States. Situated directly in the heart of South San Francisco—a premier global life sciences and biotechnology innovation cluster often recognized as the birthplace of modern biotech—this corporate facility houses the company's executive management team, clinical development leaders, regulatory affairs specialists, and administrative operations. From this headquarters location, the executive leadership coordinates its international clinical trials, engages with regulatory authorities like the U.S. Food and Drug Administration (FDA), manages relationships with global academic medical centers and contract research organizations (CROs), and oversees strategic business development initiatives for its rare disease therapeutic pipelines.