What is cretostimogene grenadenorepvec?
Cretostimogene grenadenorepvec (also known by the code name CG0070) is an investigational oncolytic immunotherapy being studied for the treatment of non-muscle invasive bladder cancer (NMIBC). It is a recombinant oncolytic adenovirus designed to selectively infect and replicate within cancer cells that have specific pathway alterations (such as Rb pathway alterations), causing those cells to burst (lysis). Additionally, it encodes for the cytokine GM-CSF, which helps stimulate an antitumor immune response. While it has shown promising results in clinical trials—including high complete response rates in BCG-unresponsive NMIBC—it remains an investigational therapy and is not yet FDA-approved.
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