What cannot mix with apple cider vinegar?

Apple cider vinegar should not be mixed with certain substances and medications because it can cause chemical reactions, reduce effectiveness, or increase side effects. You should not mix apple cider vinegar with strong alkaline cleaners like bleach or ammonia for cleaning, as mixing acid with bleach can release toxic chlorine gas that irritates lungs and can be dangerous in enclosed spaces, and mixing with baking soda for cleaning just neutralizes both and wastes them, producing mostly water and carbon dioxide. For ingestion, you should not mix apple cider vinegar directly with certain medications without medical advice, including diuretics like furosemide because vinegar can lower potassium further, insulin and diabetes drugs because it can lower blood sugar and potassium, digoxin for heart failure because low potassium increases digoxin toxicity, and some laxatives. You should not mix undiluted apple cider vinegar with toothpaste or brush immediately after drinking it because acid softens enamel. You should avoid mixing large amounts with alcohol or taking it on an empty stomach in high concentration as it can severely irritate esophagus and stomach lining. You should not mix apple cider vinegar with other highly acidic drinks in large quantities if you have acid reflux or ulcers. For topical use, do not mix undiluted vinegar with harsh essential oils or apply to open wounds as it burns tissue. Always dilute vinegar for drinking and cleaning and keep ventilation good.