Utilizing an oxygen concentrator does not introduce chemical side effects, but high-flow or poorly humidified dry oxygen can cause physical discomforts such as nasal dryness, irritation of the mucous membranes, bloody noses, skin chafing around the ears from cannula tubing, and morning throat soreness. Ensuring proper humidification attachments are integrated into stationary setups and applying water-based (non-petroleum) nasal lubricants safely mitigates these localized symptoms.