While both TULSA-PRO and High-Intensity Focused Ultrasound (HIFU) are minimally invasive thermal ablation treatments for prostate conditions, they utilize different delivery mechanisms. TULSA-PRO uses directional ultrasound guided continuously by real-time magnetic resonance imaging (MRI) with closed-loop thermal feedback to treat the entire prostate gland or targeted regions precisely. In contrast, HIFU typically relies on transrectal ultrasound guidance and focuses acoustic energy from outside or via specialized probes, making TULSA better suited for larger glands and customized whole-gland ablation.