Opening a cannabis retail dispensary in Michigan involves a total capital investment that typically ranges from several hundred thousand dollars well into six figures, depending on location, scale, and build-out requirements. State-level costs include a nonrefundable prequalification application fee of $3,000 and an initial retailer license fee of $15,000. Beyond mandatory licensing, entrepreneurs must budget heavily for commercial real estate leases, security system installations compliant with state regulations, initial product inventory, and several months of operational payroll before the business reaches profitability.