The annual interest earned on a $100,000 deposit depends entirely on the prevailing percentage yield of the chosen financial instrument. Placing the funds in a high-yield savings account or certificate of deposit yielding roughly 4.5% to 5% generates between $4,500 and $5,000 in annual interest income. Conversely, deploying that capital into riskier equities or fixed-income bonds with higher yields can yield varying returns subject to market volatility.