Hypoglossal nerve stimulation therapy—such as the Inspire sleep apnea treatment system—typically involves total costs ranging between $30,000 and $65,000 in the United States, with an average overall expense hovering around $45,000. This total figure encompasses the specialized implantable pulse generator and lead hardware components (costing $30,000 to $45,000 alone), professional surgeon fees, operating room charges, general anesthesia, and required pre-operative diagnostic evaluations like drug-induced sleep endoscopies, though most major health insurance providers offer coverage subject to specific policy criteria.