Yes, you can safely leave CLR (Calcium, Lime, and Rust remover) in a toilet bowl overnight to dissolve heavy mineral crust and hard water rings. Because CLR is formulated to break down stubborn calcium deposits, letting it soak for 8 to 12 hours loosens mineral scale without damaging porcelain ceramic. Callout type="warning" title="Hygiene Warning": Wear rubber gloves and eye protection, and keep the bathroom ventilated when working with chemical descalers. Verification: Scrub the loosened mineral scale with a toilet brush and flush the bowl clean.
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