Modern Focusrite audio interfaces feature dedicated instrument-level inputs—frequently labeled as "Inst" via software toggles or physical buttons on combo XLR inputs—that accommodate direct plugging of electric and acoustic-electric guitars. These inputs provide the correct high-impedance (Hi-Z) electrical load necessary to preserve high-frequency guitar tone and prevent signal loading, allowing players to utilize amp simulation plugins inside their DAW without needing a standalone direct injection (DI) box.