Yes, you can drive screws directly into Medium Density Fiberboard (MDF), but you must take specific precautions to prevent the material from splitting or stripping out. Because MDF is composed of compressed wood fibers and resin rather than long grain fibers, it lacks natural holding power. It is always recommended to drill pilot holes and countersink them prior to driving screws, and using specialized coarse-threaded wood screws or confirmatory screws ensures a much stronger, durable hold without compromising structural integrity.